分子影像实验室

负责人:李芬芬 博士 特任副研究员

邮箱:lifenfen@ustc.edu.cn

联系地址:中国科学技术大学中校区医学楼一楼医学影像中心

研究方向

1. 纳米探针的设计和合成

利用多种方法合成不同无机纳米材料,如铁氧化物纳米颗粒、二维纳米片、量子点等并对其表面进行修饰;合成脂质体材料及自组装纳米材料用于生物医学应用。

2. 疾病诊断及治疗

利用合成的纳米探针或纳米药物,采用不同给药方式实现探针或药物在肿瘤及炎症部位的靶向递送,通过磁共振等影像学手段实现疾病早期诊断及治疗。

文章发表

(1) H. X. Wang, W. S. Wang, C. P. Li, A. Xu, B. S. Qiu*, F. F. Li*, W. P. Ding*, Flav7+DOX co-loaded separable microneedle for light-triggered chemo-thermal therapy of superficial tumors, Chemical Engineering Journal 428 (2022).

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(2) W. S. Wang, F. F. Li*, S. B. Li, Y. Hu, M. R. Xu, Y. Y. Zhang, M. I. Khan, S. Z. Wang, M. Wu, W. P. Ding*, B. S. Qiu*, M2 macrophage-targeted iron oxide nanoparticles for magnetic resonance image-guided magnetic hyperthermia therapy, Journal of Material Science & Technology 81 (2021) 77-87.

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(3) Y. Y. Zhang, F. F. Li*, S. N. Ya, Y. Hu, D. B. Zhi, W. S. Wang, M. R. Xu, B. S. Qiu*, W. P. Ding*, An iron oxide nanoparticle-based transdermal nanoplatform for dual-modal imaging-guided chemo-photothermal therapy of superficial tumors, Acta Biomaterialia 130 (2021) 473-484.

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(4) F. F. Li#, T. W. Li#, D. B. Zhi#, P. P. Xu, W. S. Wang, Yi. Hu, Y. Y. Zhang, S. Z. Wang, J. Matula Thomas, J. Beauchamp Norman, W. P. Ding*, L. F. Yan*, B. S. Qiu*, Novel ultrasmall multifunctional nanodots for dual-modal MR/NIR-II imaging-guided photothermal therapy, Biomaterials256 (2020) 120219.

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(5) M. R. Xu, Y. Hu, Y. Xiao, Y. Y. Zhang, K. L. Sun, T. Wu, N. Lv, W. S. Wang, W. P. Ding, F. F. Li*, B. S. Qiu*, J. B. Li*, Near-Infrared-Controlled Nanoplatform Exploiting Photothermal Promotion of Peroxidase-like and OXD-like Activities for Potent Antibacterial and Anti-biofilm Therapies, ACS Applied Materials & Interfaces 12(45) (2020) 50260-50274.

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(6) F. F. Li, D. B. Zhi, Y. F. Luo, J. Q. Zhang, X. Nan, Y. J. Zhang, W. Zhou, B. S. Qiu*, L. P. Wen*, G. L. Liang*, Core/shell Fe3O4/Gd2O3 nanocubes as T1-T2 dual modal MRI contrast agents, Nanoscale 8(25) (2016) 12826-12833.

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(7) S. W. Ali, F. A. Mangrio, F. F. Li*, P. Dwivedi, M. U. Rajput, R. Ali, M. I. Khan, W. P. Ding*, R. X. Xu*, Co-delivery of artemether and piperine via core-shell microparticles for enhanced sustained release, Journal of Drug Delivery Science & Technology 63 (2020).

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